Alterations in Lipid Signaling Underlie Lipodystrophy Secondary to AGPAT2 Mutations

Abstract

Congenital generalized lipodystrophy (CGL), secondary to AGPAT2 mutation is characterized by the absence of adipocytes and development of severe insulin resistance. In the current study, we investigated the adipogenic defect associated with AGPAT2 mutations. Adipogenesis was studied in muscle-derived multipotent cells (MDMCs) isolated from vastus lateralis… (More)
DOI: 10.2337/db12-0004

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@inproceedings{Subauste2012AlterationsIL, title={Alterations in Lipid Signaling Underlie Lipodystrophy Secondary to AGPAT2 Mutations}, author={Angela R Subauste and Arun Das and Xiangquan Li and Brandon Elliot and Charles R. Evans and Mahmoud A. El Azzouny and Mary Kay Treutelaar and Elif Arioglu Oral and Todd Leff and Charles F. Burant}, booktitle={Diabetes}, year={2012} }