Alterations in Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling in patients with end-stage dilated cardiomyopathy.

@article{Podewski2003AlterationsIJ,
  title={Alterations in Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling in patients with end-stage dilated cardiomyopathy.},
  author={Edith Katharina Podewski and Denise Hilfiker-Kleiner and Andres Hilfiker and Henning Morawietz and Artur Lichtenberg and Kai C. Wollert and Helmut Drexler},
  journal={Circulation},
  year={2003},
  volume={107 6},
  pages={798-802}
}
BACKGROUND Experimental studies indicate that interleukin-6 (IL-6)-related cytokines, signaling via the shared receptor gp130, Janus kinases (JAKs), and signal transducers and activators of transcription (STATs), provide a critical cardiomyocyte survival pathway in vivo. Little is known about the activation of this signaling pathway in the myocardia of patients with end-stage dilated cardiomyopathy (DCM). METHODS AND RESULTS We performed a comprehensive expression and activation analysis of… CONTINUE READING
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