Alterations in Hepatic Metabolism in fld Mice Reveal a Role for Lipin 1 in Regulating VLDL-Triacylglyceride Secretion

@article{Chen2008AlterationsIH,
  title={Alterations in Hepatic Metabolism in fld Mice Reveal a Role for Lipin 1 in Regulating VLDL-Triacylglyceride Secretion},
  author={Z. Chen and Matthew C. Gropler and J. Norris and J. Lawrence and T. Harris and B. Finck},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology},
  year={2008},
  volume={28},
  pages={1738-1744}
}
Objective—Lipin 1 controls fatty acid metabolism in the nucleus as a transcriptional regulator and in the cytosol as an enzyme catalyzing the penultimate step in phosphoglycerol triacylglyceride (TAG) synthesis. We sought to evaluate the effects of lipin 1 on hepatic TAG synthesis and secretion by gain-of-function and loss-of-function approaches. Methods and Results—Rates of TAG synthesis were not impaired in hepatocytes isolated from adult lipin 1–deficient (fld) mice and were actually… Expand
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