Alterations in HLA-DP and HLA-DQ antigen frequency in patients with dermatitis herpetiformis.

@article{Hall1989AlterationsIH,
  title={Alterations in HLA-DP and HLA-DQ antigen frequency in patients with dermatitis herpetiformis.},
  author={R P Hall and Mark E. Sanders and Ren{\'e} J. Duquesnoy and Stephen I. Katz and Sylvia Shaw},
  journal={The Journal of investigative dermatology},
  year={1989},
  volume={93 4},
  pages={501-5}
}
Dermatitis herpetiformis (DH) is associated with a markedly increased frequency of the HLA class II antigens DR3 and DQw2. To investigate a possible role of HLA-DP (or closely associated genes) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA-DR3 and HLA-DQw2 antigen frequency, we have typed 43 patients with DH for HLA-DP, HLA-DQ, and HLA-DR antigens. All patients with DH had typical clinical and histologic features, as well as granular deposits of IgA… CONTINUE READING

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A role of HLA - DP region genes in the pathogenesis of DH is further suggested by the observation that HLA - DPw1 was expressed in 82% ( 9 of 11 ) of DH patients with IgA antibodies against dietary antigens as compared with only 33% ( 4 of 12 ) of patients without IgA antibodies .
A role of HLA - DP region genes in the pathogenesis of DH is further suggested by the observation that HLA - DPw1 was expressed in 82% ( 9 of 11 ) of DH patients with IgA antibodies against dietary antigens as compared with only 33% ( 4 of 12 ) of patients without IgA antibodies .
A role of HLA - DP region genes in the pathogenesis of DH is further suggested by the observation that HLA - DPw1 was expressed in 82% ( 9 of 11 ) of DH patients with IgA antibodies against dietary antigens as compared with only 33% ( 4 of 12 ) of patients without IgA antibodies .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
A role of HLA - DP region genes in the pathogenesis of DH is further suggested by the observation that HLA - DPw1 was expressed in 82% ( 9 of 11 ) of DH patients with IgA antibodies against dietary antigens as compared with only 33% ( 4 of 12 ) of patients without IgA antibodies .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
Alterations in HLA - DP and HLA - DQ antigen frequency in patients with dermatitis herpetiformis .
A role of HLA - DP region genes in the pathogenesis of DH is further suggested by the observation that HLA - DPw1 was expressed in 82% ( 9 of 11 ) of DH patients with IgA antibodies against dietary antigens as compared with only 33% ( 4 of 12 ) of patients without IgA antibodies .
Alterations in HLA - DP and HLA - DQ antigen frequency in patients with dermatitis herpetiformis .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
The overall distribution of HLA - DP antigens in patients with DH was significantly different from that seen in all controls and in HLA - DR3 and HLA - DQw2 controls ( p less than 0.02 ) .
The overall distribution of HLA - DP antigens in patients with DH was significantly different from that seen in all controls and in HLA - DR3 and HLA - DQw2 controls ( p less than 0.02 ) .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
Alterations in HLA - DP and HLA - DQ antigen frequency in patients with dermatitis herpetiformis .
The overall distribution of HLA - DP antigens in patients with DH was significantly different from that seen in all controls and in HLA - DR3 and HLA - DQw2 controls ( p less than 0.02 ) .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
The overall distribution of HLA - DP antigens in patients with DH was significantly different from that seen in all controls and in HLA - DR3 and HLA - DQw2 controls ( p less than 0.02 ) .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
Studies of three informative families demonstrated that the DPw2 genes of the DH patients were not present on the haplotype thought to carry a DH susceptibility gene ( HLA - A1 , HLA - B8 , HLA - DR3 , HLA - DQw2 ) .
Studies of three informative families demonstrated that the DPw2 genes of the DH patients were not present on the haplotype thought to carry a DH susceptibility gene ( HLA - A1 , HLA - B8 , HLA - DR3 , HLA - DQw2 ) .
The overall distribution of HLA - DP antigens in patients with DH was significantly different from that seen in all controls and in HLA - DR3 and HLA - DQw2 controls ( p less than 0.02 ) .
HLA - DR3 was expressed in 41 of 43 ( 95% ) DH patients , whereas HLA - DQw2 was expressed in all 43 ( 100% ) .
The overall distribution of HLA - DP antigens in patients with DH was significantly different from that seen in all controls and in HLA - DR3 and HLA - DQw2 controls ( p less than 0.02 ) .
Studies of three informative families demonstrated that the DPw2 genes of the DH patients were not present on the haplotype thought to carry a DH susceptibility gene ( HLA - A1 , HLA - B8 , HLA - DR3 , HLA - DQw2 ) .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
To investigate a possible role of HLA - DP ( or closely associated genes ) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA - DR3 and HLA - DQw2 antigen frequency , we have typed 43 patients with DH for HLA - DP , HLA - DQ , and HLA - DR antigens .
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