Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis.

@article{Astier2006AlterationsIC,
  title={Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis.},
  author={Anne L Astier and Gr{\'e}gory Meiffren and Samuel Freeman and David A. Hafler},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 12},
  pages={3252-7}
}
Loss of Treg function appears to be a critical factor in the pathogenesis of human autoimmune diseases. Attention has focused on defects of CD4(+)CD25(high) Tregs, and techniques have been developed to determine their function. In contrast, the role of Tr1 regulatory T cells, which secrete the antiinflammatory cytokine IL-10, in autoimmune disease has not… CONTINUE READING