Alterations in Acetylation of Histone H4 Lysine 8 and Trimethylation of Lysine 20 associated with Lytic Gene Promoters during Kaposi's Sarcoma-Associated Herpesvirus Reactivation.


Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with formation of Kaposi's sarcoma, multicentric Castleman's disease and primary effusion lymphoma. Replication and transcription activator (RTA) genes are expressed upon reactivation of KSHV, which displays a biphasic life cycle consisting of latent and lytic replication phases. RTA protein… (More)
DOI: 10.4014/jmb.1607.07032


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