Alterations by antidepressants of cerebrospinal fluid formation and calcium distribution dynamics in the intact rat brain.


The formation of cerebrospinal fluid (CSF) after chronic treatment with imipramine (IMI), lithium (Li), or electroshock (EST) was studied in urethane-anesthetized rats by ventricular-cisternal perfusion with 14C-inulin. Effects of these treatments on the removal of 45Ca from the cerebroventricular perfusate were also studied. The mean value for CSF… (More)


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