Alterations associated with androgen receptor gene activation in salivary duct carcinoma of both sexes: potential therapeutic ramifications.

@article{Mitani2014AlterationsAW,
  title={Alterations associated with androgen receptor gene activation in salivary duct carcinoma of both sexes: potential therapeutic ramifications.},
  author={Yoshitsugu Mitani and Pulivarthi H. Rao and Sankar N. Maity and Yu-Chen Lee and Renata Ferrarotto and Julian Post and Lisa Licitra and Scott Michael Lippman and Merrill S. Kies and Randal S. Weber and Carlos Caulin and Sue-Hwa Lin and Adel K. El-Naggar},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2014},
  volume={20 24},
  pages={
          6570-81
        }
}
PURPOSE To investigate the molecular events associated with the activation of androgen receptor (AR) as a potential therapeutic target in patients with salivary duct carcinoma (SDC). EXPERIMENTAL DESIGN Comprehensive molecular and expression analysis of the AR gene in 35 tumor specimens (20 males and 15 females) and cell lines derived from SDC using Western blotting and RT-PCR, FISH analysis, and DNA sequencing was conducted. In vitro and in vivo animal studies were also performed. RESULTS… CONTINUE READING

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