Alteration of tissue disposition of cadmium by chelating agents.

  title={Alteration of tissue disposition of cadmium by chelating agents.},
  author={Curtis D. Klaassen and Michael P. Waalkes and Louis R. Cantilena},
  journal={Environmental Health Perspectives},
  pages={233 - 242}
The effect of several chelating agents (diethyldithiocarbamic acid, DDC; nitrilotriacetic acid, NTA; 2,3-dimercaptopropanol, BAL; d,l-penicillamine, PEN; 2,3-dimercaptosuccinic acid, DMSA; ethylenediaminetetraacetic acid, EDTA; and diethylenetriaminepentaacetic acid, DTPA) on the toxicity, distribution and excretion of cadmium (Cd) was determined in mice. When chelators were administered immediately after Cd, significant increases in survival were noted after treatment with DMSA, EDTA, and DTPA… CONTINUE READING