Alteration of the tumor suppressor gene p53 in a high fraction of hormone refractory prostate cancer.

@article{Heidenberg1995AlterationOT,
  title={Alteration of the tumor suppressor gene p53 in a high fraction of hormone refractory prostate cancer.},
  author={H B Heidenberg and Isabell A. Sesterhenn and J P Gaddipati and Christopher Weghorst and Gregory S. Buzard and Judd W. Moul and Sudhir Srivastava},
  journal={The Journal of urology},
  year={1995},
  volume={154 2 Pt 1},
  pages={414-21}
}
PURPOSE We studied the role of p53 tumor suppressor gene alteration in prostate cancer progression by demonstrating a difference in abnormal p53 findings between early and hormone refractory disease. MATERIALS AND METHODS The study included p53 immunohistochemistry of 26 archival transurethral resection specimens from patients with radiation recurrent and hormone refractory disease, 27 untreated primary tumors and 8 untreated metastatic lesions. p53 mutation analysis of tumor deoxyribonucleic… CONTINUE READING