Alteration of the platelet serotonin transporter in romantic love.

@article{Marazziti1999AlterationOT,
  title={Alteration of the platelet serotonin transporter in romantic love.},
  author={Donatella Marazziti and Hagop Souren Akiskal and Alessandra Rossi and G. B. Cassano},
  journal={Psychological medicine},
  year={1999},
  volume={29 3},
  pages={
          741-5
        }
}
BACKGROUND The evolutionary consequences of love are so important that there must be some long-established biological process regulating it. Recent findings suggest that the serotonin (5-HT) transporter might be linked to both neuroticism and sexual behaviour as well as to obsessive-compulsive disorder (OCD). The similarities between an overvalued idea, such as that typical of subjects in the early phase of a love relationship, and obsession, prompted us to explore the possibility that the two… 

Tables from this paper

Decreased lymphocyte dopamine transporter in romantic lovers
TLDR
The results showed that the subjects in the early phase of romantic love had a global alteration of the lymphocyte DAT involving both a decreased number of proteins and a reduced functionality (Vmax).
Decreased Density of the Platelet Serotonin Transporter in Pathological Gamblers
TLDR
PG patients showed a dysfunction at the level of the platelet SERT that would suggest the involvement of the 5-HT system in this condition, compared with a similar group of healthy control subjects.
Current Evidence of the Monoaminergic Regulation of Romantic Love and Relationship
TLDR
Romantic love is vulnerable for secondary effect, such as drugs which modulate the dopamine and serotonin, in human, and is also impacted by the polymorphism of monoamine receptors.
Platelet Serotonergic Markers as Endophenotypes for Obsessive-Compulsive Disorder
TLDR
The presence of peripheral serotonergic abnormalities in OCD patients and their unaffected parents supports a familial origin of these disturbances, which may serve as endophenotypic markers in OCD, and could contribute to the study of the biological mechanisms and genetic underpinnings of the disorder.
Serotonin and Love: Supporting Evidence From a Patient Suffering From Obsessive-Compulsive Disorder.
TLDR
The case of a patient who developed hair pulling behavior during treatment with aripiprazole is reported, and it is likely that this was the principal mechanism involved in the present case.
Decreased Lymphocyte 3H-Paroxetine Binding in Obsessive-Compulsive Disorder
TLDR
This finding confirms previous data of an abnormal platelet 5-HT transporter in OCD and provides the possibility to explore the regulation of this structure in this and other disorders, since lymphocytes are nucleate cells.
Blood Levels of Serotonin Are Differentially Affected by Romantic Love in Men and Women
People who are in love think about their beloved the whole day, which is supposed to be associated with serotonin. The research questions were how peripheral serotonin levels differ between
Modulation of the platelet serotonin transporter by thermal balneotherapy: a study in healthy subjects.
TLDR
The results of this study suggest that SERT modifications may be related to a specific effect of ozonized water and, perhaps, also to the increased sense of well-being.
Platelet Serotonergic Predictors of Clinical Improvement in Obsessive Compulsive Disorder
TLDR
The results confirm that whole-blood 5-HT concentration is a predictor for clinical improvement and indicate that abnormal intracellular mechanisms may be involved in OCD patients, in particular, the overstimulation of the phosphoinositide signaling system.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 44 REFERENCES
Decreased platelet 3H-paroxetine binding in obsessive-compulsive patients.
TLDR
The results, showing that the patients had a lower number of 3H-paroxetine sites, which is inversely correlated with the Yale Brown Obsessive-Compulsive Scale total score, than a similar group of controls, add supporting evidence to the involvement of 5-HT in OCD.
Obsessive-compulsive disorder and serotonin: Is there a connection?
Peripheral markers of serotonin and dopamine function in obsessive-compulsive disorder
Changes in platelet markers of obsessive-compulsive patients during a double-blind trial of fluvoxamine versus clomipramine.
TLDR
The findings suggest that the reduction in 3H-IMI binding sites in OCD may be related to the severity of the illness and possibly to a positive response to serotonin re-uptake inhibitors, and might be considered as a state-dependent marker, whereas the PST activity would seem to be a trait of the disease.
Efficacy and tolerability of serotonin transport inhibitors in obsessive-compulsive disorder. A meta-analysis.
TLDR
While the results of this meta-analysis support the superiority of clomipramine, head-to-head, double-blind comparisons of these compounds would be the best test of comparative efficacy and tolerability.
Impulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet.
TLDR
Reduced numbers of platelet 5-HT transporter sites may covary with life history of aggressive behavior in patients with personality disorder and aggressive behavior.
Refining treatment approaches in obsessive‐compulsive disorder
  • N. Fineberg
  • Psychology
    International clinical psychopharmacology
  • 1996
TLDR
Attention is now shifting to the impact of side effects on efficacy, a particularly important consideration for OCD patients who require long-term medication but are frequently reluctant to lake drugs, and suggests that SSRIs are better tolerated than clomipramine and are therefore more likely to lead to a favourable treatment outcome.
Obsessive-compulsive disorder: psychobiological approaches to diagnosis, treatment, and pathophysiology
New developments in obsessive‐compulsive disorder research: implications for clinical management
TLDR
Some of the recent developments which have enhanced the understanding of OCD are reviewed and their potential impact on clinical management is considered.
...
1
2
3
4
5
...