Alteration of the parasite plasma membrane and the parasitophorous vacuole membrane during exo-erythrocytic development of malaria parasites.

@article{Sturm2009AlterationOT,
  title={Alteration of the parasite plasma membrane and the parasitophorous vacuole membrane during exo-erythrocytic development of malaria parasites.},
  author={Angelika Sturm and Stefanie Graewe and Blandine M.D. Franke-Fayard and Silke Retzlaff and Stefanie Bolte and Bernhard Roppenser and Martin Aepfelbacher and Chris Janse and Volker T Heussler},
  journal={Protist},
  year={2009},
  volume={160 1},
  pages={51-63}
}
The rodent malaria parasite Plasmodium berghei develops in hepatocytes within 48-52h from a single sporozoite into up to 20,000 daughter parasites, so-called merozoites. The cellular and molecular details of this extensive proliferation are still largely unknown. Here we have used a transgenic, RFP-expressing P. berghei parasite line and molecular imaging techniques including intravital microscopy to decipher various aspects of parasite development within the hepatocyte. In late schizont stages… CONTINUE READING

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