Alteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study.

@article{Picard2006AlterationOT,
  title={Alteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study.},
  author={Fabienne Picard and Dominique Bruel and Denis Servent and Waddah Saba and Carole Fruchart-Gaillard and M-A Sch{\"o}llhorn-Peyronneau and Dimitri Roumenov and Eilif M. Brodtkorb and Saleem Zuberi and Antonio Gambardella and Barbara Steinborn and Andreas Hufnagel and H{\'e}ric Valette and Michel Bottlaender},
  journal={Brain : a journal of neurology},
  year={2006},
  volume={129 Pt 8},
  pages={
          2047-60
        }
}
Nicotinic acetylcholine receptors (nAChRs) are involved in a familial form of frontal lobe epilepsy, autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). In several ADNFLE families, mutations were identified in the nAChR alpha4 or beta2 subunit, which together compose the main cerebral nAChR. Electrophysiological assessment using in vitro expression systems indicated a gain of function of the mutant receptors. However the precise mechanisms by which they contribute to the pathogenesis… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 69 REFERENCES

In vivo imaging of human cerebral nicotinic acetylcholine receptors with 2-18F-fluoro-A-85380 and PET.

  • Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 2005
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Recently defined genetic epileptic syndromes

F Picard, I. Scheffer
  • Montrouge: John Libbey Eurotext;
  • 2005
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

High-efficiency transformation of mammalian cells by plasmid DNA.

  • Molecular and cellular biology
  • 1987
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

A sensitive and specific quantification of unchanged [ 18 F ]fluoroA85380 in plasma by solid phase extraction for human PET studies

M Schöllhorn-Peyronneau, C Coulon, +3 authors Deverre
  • Eur J Nucl Med
  • 2005

Cholinergic and non

Y Abstract. Smith, D Pare, M Deschenes, A Parent, M. Steriade
  • Eur J Nucl Med
  • 2005