Alteration of the copy number and deletion of mitochondrial DNA in human hepatocellular carcinoma

  title={Alteration of the copy number and deletion of mitochondrial DNA in human hepatocellular carcinoma},
  author={Pen-Hui Yin and H C Lee and G Y Chau and Y T Wu and Shuan-yow Li and W. Y. Lui and Yau-Huei Wei and Tiffany Yi-Chen Liu and C W Chi},
  journal={British Journal of Cancer},
  pages={2390 - 2396}
Somatic mutations in mitochondrial DNA (mtDNA) have been detected in hepatocellular carcinoma (HCC). However, it remains unclear whether mtDNA copy number and mitochondrial biogenesis are altered in HCC. In this study, we found that mtDNA copy number and the content of mitochondrial respiratory proteins were reduced in HCCs as compared with the corresponding non-tumorous livers. MtDNA copy number was significantly reduced in female HCC but not in male HCC. Expression of the peroxisome… CONTINUE READING


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