Alteration of the TGF-beta/SMAD pathway in intrinsically and UV-induced skin aging.

@article{Han2005AlterationOT,
  title={Alteration of the TGF-beta/SMAD pathway in intrinsically and UV-induced skin aging.},
  author={Kwang-Ho Han and Hye-Ryung Choi and C D Won and Jin-Ho Chung and K H Cho and H E Eun and Kyu Han Kim},
  journal={Mechanisms of ageing and development},
  year={2005},
  volume={126 5},
  pages={560-7}
}
In an effort to characterize transforming growth factor (TGF-beta) signaling and to determine its association with the aging and photoaging processes, we directly compared the expressions of TGF-beta/SMAD in intrinsically aged and photoaged human skin in vivo. By using an RNase protection assay and by immunohistochemistry, we found that the expression levels of TbetaRII mRNA and protein in the epidermis of the forearm (sun-exposed) of the elderly were significantly lower than that of the upper… CONTINUE READING

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