Alteration of the MT1 melatonin receptor gene and its expression in primary human breast tumors and breast cancer cell lines

@article{Lai2008AlterationOT,
  title={Alteration of the MT1 melatonin receptor gene and its expression in primary human breast tumors and breast cancer cell lines},
  author={Ling Lai and Lin Yuan and Qi Cheng and Chunmin Dong and Lulu Mao and Steven Marc Hill},
  journal={Breast Cancer Research and Treatment},
  year={2008},
  volume={118},
  pages={293-305}
}
The MT1 melatonin receptor is bound and activated by the pineal hormone melatonin. This G protein-coupled melatonin receptor is expressed in human breast tumor cell lines, and when activated, mediates the growth-suppressive and steroid hormone/nuclear receptor modulatory actions of melatonin on breast tumor cells. In the current studies, we have examined the expression of the MT1 receptor in breast cancer cell lines and primary human breast tumors and correlated MT1 receptor expression with the… CONTINUE READING
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