Alteration of the α-Synuclein Folding Landscape by a Mutation Related to Parkinson’s Disease**

a-Synuclein is an abundant presynaptic protein that is associated with several biological activities, including vesicle trafficking, maintenance of synaptic SNARE complexes and vesicle pools, and regulation of dopamine metabolism. The protein is believed to play a central role in the pathogenesis of Parkinson s disease (PD), as evidenced by the… CONTINUE READING