Alteration of testicular steroidogenesis and histopathology of reproductive system in male rats treated with triclosan.

@article{Kumar2009AlterationOT,
  title={Alteration of testicular steroidogenesis and histopathology of reproductive system in male rats treated with triclosan.},
  author={Vikas Kumar and Ajanta Chakraborty and Mool Raj Kural and Partha Jit Roy},
  journal={Reproductive toxicology},
  year={2009},
  volume={27 2},
  pages={177-85}
}
Triclosan (TCS), a chlorophenol, is widely used as a preservative in different types of commercial preparations. The reports on TCS-mediated endocrine disruption are controversial and the present study aimed to elucidate the probable mode of action of TCS as an antiandrogenic compound using a robust study design. Male albino rats, Rattus norvegicus, were treated with three doses of triclosan for a period of 60 days followed by the analysis of various biochemical parameters. RT-PCR analysis… CONTINUE READING