Alteration of surfactant function due to protein leakage: special interaction with fibrin monomer.

@article{Seeger1985AlterationOS,
  title={Alteration of surfactant function due to protein leakage: special interaction with fibrin monomer.},
  author={Werner Seeger and Gabriele Stoehr and H. de Wolf and Heinz Neuhof},
  journal={Journal of applied physiology},
  year={1985},
  volume={58 2},
  pages={326-38}
}
In isolated rabbit lungs standardized amounts of edema were induced. Stimulation with the Ca ionophore A23187, leukotriene C4, Pseudomonas aeruginosa cytotoxin and human serum (activated complement) all resulted in protein leakage into the alveolar space with no change in the total phospholipid content. The pressure-volume characteristics of the lungs and the characteristics of the lavage surfactant (Wilhelmy balance) were markedly altered, correlating to the lavage protein content. The… CONTINUE READING

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