Alteration of right ventricular-pulmonary vascular coupling in a porcine model of progressive pressure overloading.

@article{Ghuysen2008AlterationOR,
  title={Alteration of right ventricular-pulmonary vascular coupling in a porcine model of progressive pressure overloading.},
  author={Alexandre Ghuysen and Bernard C. Lambermont and Philippe Kolh and Vincent Tchana-Sato and David Magis and Paul E Gerard and V{\'e}ronique Mommens and Nathalie Janssen and Thomas Desaive and Vincent D'orio},
  journal={Shock},
  year={2008},
  volume={29 2},
  pages={197-204}
}
In acute pulmonary embolism, right ventricular (RV) failure may result from exceeding myocardial contractile resources with respect to the state of vascular afterload. We investigated the adaptation of RV performance in a porcine model of progressive pulmonary embolism. Twelve anesthetized pigs were randomly divided into two groups: gradual pulmonary arterial pressure increases by three injections of autologous blood clot (n=6) or sham-operated controls (n=6). Right ventricular pressure-volume… CONTINUE READING
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