Alteration of respiratory cycle timing by propranolol.

  title={Alteration of respiratory cycle timing by propranolol.},
  author={Michelle M. Schaper and K. N. Detwiler and Yves Alarie},
  journal={Toxicology and applied pharmacology},
  volume={97 3},
The present study was undertaken to explore the effect of propranolol on respiratory cycle timing and breathing pattern using mice and guinea pigs. Propranolol was administered via aerosol or via injection. Mice exposed to propranolol aerosols exhibited a breathing pattern that was characterized by a pause between breaths. The length of such pauses (TP) increased as the propranolol exposure concentration was raised. We also observed at increasing propranolol concentrations that the time of… CONTINUE READING