Alteration of pituitary-adrenal responses to adrenalectomy by the immunological targeting of CRF neurons.

Abstract

We previously demonstrated that cellular toxins added to a cytotoxic IgG2a monoclonal antibody to corticotropin releasing factor (CRF-MAb) may specifically penetrate some hypothalamic CRF neurons, after central injection near the paraventricular nuclei. We attempt here to evaluate the consequential effects on the CRF neurons functioning. Such a toxic mix, 4 weeks after its central injection, caused a marked reduction (66%) of the chronic adrenocorticotropic hormone (ACTH) release in response to a bilateral adrenalectomy (7th day). This change was accompanied by a reduction in the CRF concentration (43%) measured in the median eminence. We concluded that specific internalization of toxins, by the way of CRF-MAb, leads to a long-term dysregulation of the CRF synthesis and/or neuronal transport.

Cite this paper

@article{Menzaghi1992AlterationOP, title={Alteration of pituitary-adrenal responses to adrenalectomy by the immunological targeting of CRF neurons.}, author={Frederique M Menzaghi and Arlette Burlet and Mich{\`e}le Chapleur and J P Nicolas and Corinne Burlet}, journal={Neuroscience letters}, year={1992}, volume={135 1}, pages={49-52} }