Alteration of lung mechanics by protein-calorie malnutrition in weaned rats.

Abstract

The influence of protein-calorie malnutrition on lung development was studied in weaned rats. From the age of 28 days, they received ad libitum a diet containing 15 or 5% proteins (P15 or P5) or half of the high-protein diet (1/2 P15). After one month, lung weight and lung protein and DNA content were decreased in test animals, but DNA concentration was increased. These lungs appeared to have a higher density of smaller cells. V-P curves were performed on excised lungs. With air-filling, the curves obtained in 1/2 P15 and P5 rats were shifted downward and to the right even when expressed as percent of maximal volume. Their exponential analysis assessed the decrease in compliance. With saline-filling, V-P curves were similarly shifted except at low volumes. Both in P5 and 1/2 P15 rats, the pressure at lung rupture after air- or saline-filling was increased. In conclusion, protein-calorie malnutrition started after weaning interferes with lung development, causing an increase in surface and tissue elastic forces and in resistance to rupture.

Statistics

0200400'89'92'95'98'01'04'07'10'13'16
Citations per Year

445 Citations

Semantic Scholar estimates that this publication has 445 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Kalenga1987AlterationOL, title={Alteration of lung mechanics by protein-calorie malnutrition in weaned rats.}, author={Masendu Kalenga and J. C. Henquin}, journal={Respiration physiology}, year={1987}, volume={68 1}, pages={29-39} }