Alteration of intracellular Na+ during ischemia in diabetic rat hearts: the role of reduced activity in Na+/H+ exchange against stunning.

@article{Imahashi1998AlterationOI,
  title={Alteration of intracellular Na+ during ischemia in diabetic rat hearts: the role of reduced activity in Na+/H+ exchange against stunning.},
  author={Ken-ichi Imahashi and Katsuji Hashimoto and Hiroichiro Yamaguchi and Tsunehiko Nishimura and Hideo Kusuoka},
  journal={Journal of molecular and cellular cardiology},
  year={1998},
  volume={30 3},
  pages={
          509-17
        }
}
To elucidate the contribution of reduced activity of Na+/H+ exchange in streptozotocin-induced diabetic hearts against stunning, intracellular Na+ concentration ([Na+]i) was measured in isolated rat hearts using 23Na-MRS. The recovery of left ventricular developed pressure in hearts reperfused after 15 min global ischaemia at 37 degreesC was significantly better in diabetic ones (102.9+/-2.0% of pre-ischemic level, mean+/-s.e., n=6; P<0.05), and non-diabetic ones pre-treated with potent Na+/H… CONTINUE READING
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