Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice.

Abstract

Factors that determine the spectrum of target organs involved in autoimmune destruction are poorly understood. Although loss of function of autoimmune regulator (AIRE) in thymic epithelial cells is responsible for autoimmunity, the pathogenic roles of AIRE in regulating target-organ specificity remain elusive. In order to gain insight into this issue, we… (More)

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Cite this paper

@article{Niki2006AlterationOI, title={Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice.}, author={Shino Niki and Kiyotaka Oshikawa and Yasuhiro Mouri and F. Hirota and Akemi Matsushima and Masashi Yano and Hongwei Han and Yoshimi Bando and Keisuke Izumi and Masaki Matsumoto and K. Nakayama and Noriyuki Kuroda and Mitsuru Matsumoto}, journal={The Journal of clinical investigation}, year={2006}, volume={116 5}, pages={1292-301} }