Alteration of hsp82 gene expression by the gypsy transposon and suppressor genes in Drosophila melanogaster.

@article{Dorsett1989AlterationOH,
  title={Alteration of hsp82 gene expression by the gypsy transposon and suppressor genes in Drosophila melanogaster.},
  author={Dale Dorsett and Gregory A. Viglianti and B J Rutledge and Matthew Meselson},
  journal={Genes & development},
  year={1989},
  volume={3 4},
  pages={454-68}
}
Several mutations in Drosophila result from insertion of the gypsy retrotransposon. Gypsy insertion mutagenesis and its modulation by allele-specific modifier genes were investigated by inserting gypsy or fragments of it into the intron of the Drosophila hsp82 heat shock gene. With gypsy in the parallel orientation, nearly all transcripts in transfected cells and transformed pupae were truncated in the 5' long terminal repeat (LTR). Truncation also occurred in or near the 3' LTR. The 5' LTR… CONTINUE READING

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