Alteration of glycolipids in ras-transfected NIH 3T3 cells.

@article{Matyas1987AlterationOG,
  title={Alteration of glycolipids in ras-transfected NIH 3T3 cells.},
  author={Gary R. Matyas and Stuart A. Aaronson and Roscoe O. Brady and Peter H. Fishman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 17},
  pages={
          6065-8
        }
}
  • G. Matyas, S. Aaronson, +1 author P. Fishman
  • Published 1987
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Glycosphingolipid alterations upon viral transformation are well documented. Transformation of mouse 3T3 cells with murine sarcoma viruses results in marked decreases in the levels of gangliosides GM1 and GD1a and an increase in gangliotriaosylceramide. The transforming oncogenes of these viruses have been identified as members of the ras gene family. We analyzed NIH 3T3 cells transfected with human H-, K- and N-ras oncogenes for their glycolipid composition and expression of cell surface… Expand
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