Alteration of gene expression in rat mammary tumors induced by N-methyl-N-nitrosourea.

@article{Young1996AlterationOG,
  title={Alteration of gene expression in rat mammary tumors induced by N-methyl-N-nitrosourea.},
  author={Lindon H. Young and Xiaodong Yang and Jeffrey M. Voigt},
  journal={Molecular carcinogenesis},
  year={1996},
  volume={15 4},
  pages={251-60}
}
Rodents are susceptible to the effects of chemical carcinogens and have been widely used in the study of mammary-gland carcinogenesis. However, little information is available regarding specific phenotypic changes that occur during mammary-gland carcinogenesis. In this study, subtraction hybridization was used to identify specific genes whose expression in N-methyl-N-nitrosourea (MNU)-induced rat mammary tumors had been altered. mRNA isolated from normal rat mammary tissue and tumors induced by… CONTINUE READING