Alteration of flow-induced dilatation in mesenteric resistance arteries of L-NAME treated rats and its partial association with induction of cyclo-oxygenase-2.

@article{Henrion1997AlterationOF,
  title={Alteration of flow-induced dilatation in mesenteric resistance arteries of L-NAME treated rats and its partial association with induction of cyclo-oxygenase-2.},
  author={Daniel Henrion and Elsa Dechaux and Fiona J Dowell and J Maclour and Jane Lise Samuel and Bernard I L{\'e}vy and J B Michel},
  journal={British journal of pharmacology},
  year={1997},
  volume={121 1},
  pages={83-90}
}
1. We investigated the response to pressure (myogenic tone) and flow of rat mesenteric resistance arteries cannulated in an arteriograph which allowed the measurement of intraluminal diameter for controlled pressures and flows. Rats were treated for 3 weeks with NG-nitro-L-arginine methyl ester (L-NAME, 50 mg kg-1 day-1) or L-NAME plus the angiotensin I converting enzyme inhibitor (ACEI) quinapril (10 mg kg-1 day-1). 2. Mean blood pressure increased significantly in chronic L-NAME-treated rats… CONTINUE READING