Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance.

Abstract

PURPOSE To determine the effects of high-dose cyclosporine (CsA) infusion on the pharmacokinetics of etoposide in patients with cancer. PATIENTS AND METHODS Sixteen patients were administered 20 paired courses of etoposide and CsA/etoposide. Etoposide was administered daily for three days, alone or with CsA, which was delivered by a loading dose and 3-day… (More)

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@article{Lum1992AlterationOE, title={Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance.}, author={Bertram L Lum and Sonja Kaubisch and Alan M. Yahanda and Kenneth Adler and L L Jew and Moudi Ehsan and Nathalie A. Brophy and Joanne Halsey and Michael P. Gosland and Branimir Sikic}, journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology}, year={1992}, volume={10 10}, pages={1635-42} }