Alteration of dorsal root ganglion P2X3 receptor expression and function following spinal nerve ligation in the rat

@article{Kage2002AlterationOD,
  title={Alteration of dorsal root ganglion P2X3 receptor expression and function following spinal nerve ligation in the rat},
  author={Karen L Kage and Wende Niforatos and Chang Zhen Zhu and Kevin J. Lynch and Prisca Honore and Michael F. Jarvis},
  journal={Experimental Brain Research},
  year={2002},
  volume={147},
  pages={511-519}
}
One subtype of ATP-gated ion channel, the P2X3 receptor, is expressed primarily on peripheral sensory neurons. While it is known that P2X3 receptors can participate in certain forms of nociceptive signaling, their involvement in neuropathic pain transmission is not known. We have examined the expression and function of P2X3 receptors in a rat spinal nerve ligation model of neuropathic pain. Fourteen days following L5/L6 spinal nerve ligation, the corresponding dorsal root ganglia (DRG) were… CONTINUE READING

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