Alteration of cytosolic free calcium homeostasis by SIN‐1: high sensitivity of L‐type Ca2+ channels to extracellular oxidative/nitrosative stress in cerebellar granule cells

@article{GutirrezMartn2005AlterationOC,
  title={Alteration of cytosolic free calcium homeostasis by SIN‐1: high sensitivity of L‐type Ca2+ channels to extracellular oxidative/nitrosative stress in cerebellar granule cells},
  author={Yolanda Guti{\'e}rrez-Mart{\'i}n and Francisco Javier Martin-Romero and Fernando Henao and Carlos Guti{\'e}rrez-Merino},
  journal={Journal of Neurochemistry},
  year={2005},
  volume={92}
}
Exposure of cerebellar granule neurones in 25 mm KCl HEPES‐containing Locke's buffer (pH 7.4) to 50–100 µm SIN‐1 during 2 h decreased the steady‐state free cytosolic Ca2+ concentration ([Ca2+]i) from 168 ± 33 nm to 60 ± 10 nm, whereas exposure to ≥ 0.3 mm SIN‐1 produced biphasic kinetics: (i) decrease of [Ca2+]i during the first 30 min, reaching a limiting value of 75 ± 10 nm (due to inactivation of L‐type Ca2+ channels) and (ii) a delayed increase of [Ca2+]i at longer exposures, which… 
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