Alteration of circulating miRNAs in SSc: miR-30b regulates the expression of PDGF receptor β.

@article{Tanaka2013AlterationOC,
  title={Alteration of circulating miRNAs in SSc: miR-30b regulates the expression of PDGF receptor β.},
  author={Shigeru Tanaka and Akira Suto and Kei Ikeda and Yoshie Sanayama and Daiki Nakagomi and Taro Iwamoto and Kotaro Suzuki and Naotomo Kambe and Hiroyuki Matsue and Ryutaro Matsumura and Daisuke Kashiwakuma and Itsuo Iwamoto and Hiroshi Nakajima},
  journal={Rheumatology},
  year={2013},
  volume={52 11},
  pages={1963-72}
}
OBJECTIVE Although several miRNAs have been shown to regulate autoimmune pathogenesis by affecting lymphocyte function, the roles of miRNAs in the pathogenesis of SSc remain unclear. Therefore the purpose of this study was to identify miRNAs that play a role in the pathogenesis of SSc by quantitative PCR screening of serum miRNAs. METHODS Ninety-five miRNAs that were predicted to target SSc-related genes [IL-4, TGF-β, CTGF, PDGF-B, PDGF receptor (PDGFR) α/β and COL1A2) by in silico analyses… CONTINUE READING

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