Alteration of chromosome arm 6p is characteristic of primary mediastinal B-cell lymphoma, as identified by genome-wide allelotyping.

@article{Rigaud2001AlterationOC,
  title={Alteration of chromosome arm 6p is characteristic of primary mediastinal B-cell lymphoma, as identified by genome-wide allelotyping.},
  author={Gildas Rigaud and Patrick S Moore and Domenica Taruscio and Maria Scardoni and Marina Montresor and Fabio Menestrina and Aldo Scarpa},
  journal={Genes, chromosomes & cancer},
  year={2001},
  volume={31 2},
  pages={191-5}
}
Five cases of primary mediastinal B-cell lymphoma (PMBL) each have been studied with 375 microsatellite markers from all 22 autosomes. Of the 151 genomic alterations among the 1,875 assays, only five were allelic losses. The remainder of the microsatellite alterations consisted of 114 allelic imbalances and 32 instabilities. Microsatellite alterations were found in all cases on chromosomal arms 6p and 9p. These allelic imbalances most likely are indicative of genetic amplification, a finding… CONTINUE READING
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