Alteration of cell-cycle regulatory proteins in human oral epithelial cells immortalized by HPV16 E6 and E7.

@article{Sdek2006AlterationOC,
  title={Alteration of cell-cycle regulatory proteins in human oral epithelial cells immortalized by HPV16 E6 and E7.},
  author={Patima Sdek and Zhi Yuan Zhang and Jia Cao and Hsin Pan and W. T. Chen and Jia Wei Zheng},
  journal={International journal of oral and maxillofacial surgery},
  year={2006},
  volume={35 7},
  pages={653-7}
}
E6 and E7 oncoproteins from high-risk human papillomavirus (HPV) can transform cells in tissue culture and induce tumors in vivo by abrogating the cell-cycle checkpoint. To investigate the impact of HPV16 E6 and E7 on the cell-cycle regulatory machinery in oral epithelial cells, normal human oral epithelial cells were transfected with HPV16 E6 and E7 open reading frames, and alterations in cell-cycle regulatory proteins in cells expressing HPV16 E6 and E7 were analyzed. E6 and E7 expression… CONTINUE READING
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