Alteration of cGMP metabolism during chondrogenic differentiation of chondroprogenitor-like EC cells, ATDC5.

@article{Fujishige1999AlterationOC,
  title={Alteration of cGMP metabolism during chondrogenic differentiation of chondroprogenitor-like EC cells, ATDC5.},
  author={Kotomi Fujishige and Jun Kotera and Noriyuki Yanaka and Hiroyuki Akatsuka and Kenji Omori},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1452 3},
  pages={219-27}
}
Guanosine 3',5'-cyclic monophosphate (cGMP) has been recently reported to be involved in bone formation. ATDC5 cells were used to investigate cGMP metabolism during chondrogenic differentiation. Natriuretic peptide receptor (NPR)-A and NPR-B coupled with guanylate cyclase (GC) mediate biological functions of NPs, whereas NPR-C uncoupled with GC is thought to be the clearance receptor for NPs. The amounts of NPR-A, NPR-B, and CNP transcripts were increased but the amount of NPR-C transcripts was… CONTINUE READING
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