Alteration of an essential NK cell signaling pathway by low doses of tributyltin in human natural killer cells.

@article{Aluoch2006AlterationOA,
  title={Alteration of an essential NK cell signaling pathway by low doses of tributyltin in human natural killer cells.},
  author={Aloice O. Aluoch and Sabah O. Odman-Ghazi and Margaret M Whalen},
  journal={Toxicology},
  year={2006},
  volume={224 3},
  pages={
          229-37
        }
}
Tributyltin (TBT), a toxic and widespread environmental contaminant, has been shown to inhibit natural killer (NK) cell cytotoxic function significantly. Inhibition of NK cell cytotoxic function has the potential to increase viral infections and tumor growth. Upon NK cell binding to lysis-sensitive tumor cells, an intracellular pathway is activated, which generally begins with activation of non-receptor protein tyrosine kinases (PTKs) and ends with mitogen-activated protein kinase (MAPK… CONTINUE READING
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