Alteration of a novel dispensable mitochondrial ribosomal small-subunit protein, Rsm28p, allows translation of defective COX2 mRNAs.

@article{Williams2005AlterationOA,
  title={Alteration of a novel dispensable mitochondrial ribosomal small-subunit protein, Rsm28p, allows translation of defective COX2 mRNAs.},
  author={Elizabeth H Williams and Nada Bsat and Nathalie Bonnefoy and Christine A Butler and Thomas D. Fox},
  journal={Eukaryotic cell},
  year={2005},
  volume={4 2},
  pages={
          337-45
        }
}
Mutations affecting the RNA sequence of the first 10 codons of the Saccharomyces cerevisiae mitochondrial gene COX2 strongly reduce translation of the mRNA, which encodes the precursor of cytochrome c oxidase subunit II. A dominant chromosomal mutation that suppresses these defects is an internal in-frame deletion of 67 codons from the gene YDR494w. Wild-type YDR494w encodes a 361-residue polypeptide with no similarity to proteins of known function. The epitope-tagged product of this gene, now… CONTINUE READING

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