Alteration of TEAD1 Expression Levels Confers Apoptotic Resistance through the Transcriptional Up-Regulation of Livin

@inproceedings{Malt2012AlterationOT,
  title={Alteration of TEAD1 Expression Levels Confers Apoptotic Resistance through the Transcriptional Up-Regulation of Livin},
  author={Andr{\'e} Landin Malt and Julie Cagliero and Kevin Legent and J{\"o}el Silber and Alain Zider and Domenico Flagiello},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND TEA domain (TEAD) proteins are highly conserved transcription factors involved in embryonic development and differentiation of various tissues. More recently, emerging evidences for a contribution of these proteins towards apoptosis and cell proliferation regulation have also been proposed. These effects appear to be mediated by the interaction between TEAD and its co-activator Yes-Associated Protein (YAP), the downstream effector of the Hippo tumour suppressor pathway. METHODOLOGY… CONTINUE READING
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