Alteration of Synaptosomal Plasma Membrane Cholesterol Content: Membrane Physical Properties and Cation Transport Proteins

@article{Shapiro1981AlterationOS,
  title={Alteration of Synaptosomal Plasma Membrane Cholesterol Content: Membrane Physical Properties and Cation Transport Proteins},
  author={H. Shapiro and R. Barchi},
  journal={Journal of Neurochemistry},
  year={1981},
  volume={36}
}
Abstract: The level of nerve membrane cholesterol was altered by in vitro incubation of rat brain synaptosomal plasma membrane with liposomes having varying cholesterol contents. The normal plasma membrane cholesterol/phospholipid ratio of 0.3–0.4 (mol/mol) could be decreased by about one‐half or increased more than 100%. Fluorescence polarization measurements were made using the probe 1,6‐diphenyl‐1,3,5‐hexatriene. At temperatures below 35°C, lowering membrane cholesterol led to increased… Expand

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