Alteration of Mrp2 and P-gp expression, including expression in remote organs, after intestinal ischemia-reperfusion.

@article{Ogura2008AlterationOM,
  title={Alteration of Mrp2 and P-gp expression, including expression in remote organs, after intestinal ischemia-reperfusion.},
  author={Jiro Ogura and Masaki Kobayashi and Shirou Itagaki and Takeshi Hirano and Ken Iseki},
  journal={Life sciences},
  year={2008},
  volume={82 25-26},
  pages={1242-8}
}
The present study was carried out in order to identify the changes in expression of multidrug resistance-associated protein (Mrp) 2 and P-glycoprotein (P-gp) in the intestine and remote organs after intestinal ischemia-reperfusion (I/R). Mrp2 expression in the jejunum and liver was decreased at 6 h after I/R. This decrease in Mrp2 expression was associated with an increase in the serum level of IL-6. These results suggest that the decreased Mrp2 expression after intestinal I/R was regulated by… CONTINUE READING