Alteration of BACE 1-dependent NRG 1 / ErbB 4 signaling and schizophrenia-like phenotypes in BACE 1-null mice

@inproceedings{Savonenko2008AlterationOB,
  title={Alteration of BACE 1-dependent NRG 1 / ErbB 4 signaling and schizophrenia-like phenotypes in BACE 1-null mice},
  author={Alena V. Savonenko and Tatiana Melnikova and Fiona M Laird and K. Stewart and Donald L. Price and Philip Chuen Yung Wong},
  year={2008}
}
-Site APP-cleaving enzyme 1 (BACE1) is required for the penultimate cleavage of the amyloidprecursor protein (APP) leading to the generation of amyloidpeptides that is central to the pathogenesis of Alzheimer’s disease. In addition to its role in endoproteolysis of APP, BACE1 participates in the proteolytic processing of neuregulin 1 (NRG1) and influences the myelination of central and peripheral axons. Although NRG1 has been genetically linked to schizophrenia and NRG1 / mice exhibit a number… CONTINUE READING

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Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia

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