Alteration of [14C]-testosterone metabolism after chronic exposure of Daphnia magna to tributyltin.

@article{Oberdrster1998AlterationO,
  title={Alteration of [14C]-testosterone metabolism after chronic exposure of Daphnia magna to tributyltin.},
  author={Eva Oberd{\"o}rster and Daniel P Rittschof and Gerald A. LeBlanc},
  journal={Archives of environmental contamination and toxicology},
  year={1998},
  volume={34 1},
  pages={21-5}
}
Tributyltin (TBT) is a marine biocide that has been shown to alter the activity of cytochrome P450 monooxygenases and elicit toxicity indicative of androgenization in some species. The present study was conducted to determine whether TBT altered P450-, reductase-, and transferase-mediated testosterone metabolic processes in Daphnia magna at sublethal exposure concentrations. Two generations of daphnids were continuously exposed for 21 days to nominal TBT concentrations ranging from 0.31 to 2.5… CONTINUE READING

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