Alteration in serum levels of ICAM-1 and P-, E- and L-selectins in seriously eye-injured long-term following sulfur-mustard exposure.

  title={Alteration in serum levels of ICAM-1 and P-, E- and L-selectins in seriously eye-injured long-term following sulfur-mustard exposure.},
  author={Fatemeh Heidary and Sussan Kaboudanian Ardestani and Hassan Ghasemi and Mohammad Ali Javadi and Mahmoud Mahmoudi and Roya Yaraee and Jalaledin Shams and Faramarz Falahi and Mohamad Reza Sedighi Moghadam and Shamsa Shariatpanahi and Raheleh Shakeri and Mohammad Mehdi Naghizadeh and Tooba Ghazanfari},
  journal={International immunopharmacology},
INTRODUCTION In this study, the serum levels of soluble intercellular adhesion molecule 1 (ICAM-1), P-, E-, and L-selectins were investigated in seriously eye-injured patients exposed to sulfur mustard (SM). MATERIAL AND METHODS A total of 128 individuals with SM-induced serious eye injuries and 31 healthy male controls were included in this study. The serum concentration of soluble forms of adhesion molecules was measured by enzyme-linked immunosorbent assay (ELISA) method. RESULT The… 


Alterations in the serum levels of soluble L, P and E-selectin 20 years after sulfur mustard exposure: Sardasht-Iran Cohort Study.
The change in the pattern of selectins in the SM exposed group in comparison to the control group may indicate suppressed acute inflammatory condition in which new remodeling of cytokine expression play a more crucial role in the immune-regulation.
Alterations in serum levels of inflammatory cytokines (TNF, IL-1alpha, IL-1beta and IL-1Ra) 20 years after sulfur mustard exposure: Sardasht-Iran cohort study.
The serum pro- inflammatory cytokine levels were significantly lower in the exposed group than in controls (p<0.01), and the observed down-regulation of pro-inflammatory cytokines should be considered in interpretation of diagnosis and therapeutic measures taken to improve clinical complications.
The relationship of soluble ICAM-1, VCAM-1, P-selectin and E-selectin to cardiovascular disease risk factors in healthy men and women
The concentration of soluble CAMs, particularly sICAM-1 and sESEL, reflect the level of established CVD risk factors in apparently healthy men and women, adding to the evidence that these factors contribute to CVD through their inflammatory effects on the vascular endothelium.
Association of ophthalmic complications in patients with sulfur mustard induced mild ocular complications and serum soluble adhesion molecules: Sardasht-Iran Cohort Study.
It seems that the changes in the E- and P-selectins is a regulatory mechanism for inhibition of SM induced ocular problems, although the local levels are more important and further investigations required in more severe ocular Problems in SM exposed patients.
Soluble ICAM-1 serum levels in patients with intermediate uveitis
The measurement of both sICAM-1 and IL-8 can be used as a marker for ocular disease activity and for a predisposition of developing an associated systemic disease in intermediate uveitis patients.
Soluble L-selectin is present in human plasma at high levels and retains functional activity
The presence of serum sL-selectin with functional activity indicates a potential role for sL -selectin in the regulation of leukocyte attachment to endothelium.
Cell adhesion molecules in subretinal fluid: Soluble forms of VCAM-1 (vascular cell adhesion molecule-1) and L-selectin
The present study supports growing evidence that these cell adhesion molecules are involved in the inflammatory process during the development and progression of PVR.
Soluble P-selectin as a marker of in vivo platelet activation.
BACKGROUND Platelets are the major source of circulating sP-selectin. Elevated levels of this protein have been found in many atherothrombotic disorders. Thus, we investigated whether sP-selectin
Leukocyte adhesion molecules in diseased corneas.
Investigation of the presence and distribution of intercellular adhesion molecule-1, E-selectin, and VCAM-1 in various corneas with various inflammatory and degenerative diseases demonstrates that ICAM- 1, E theselectin and VCam-1 are expressed in diseasedCorneas, often in areas of inflammation.
Association of serum immunoglobulins levels and eye injuries in sulfur mustard exposed: Sardasht-Iran Cohort Study.
It was showed that even 20 years after SM exposure serum immunoglobulins are different from matched normal controls and the levels of IgM and IgG4 are associated with some aspects of ocular surface problems.