Alteration in regulatory T cells and programmed cell death 1-expressing regulatory T cells in active generalized vitiligo and their clinical correlation.

@article{Tembhre2015AlterationIR,
  title={Alteration in regulatory T cells and programmed cell death 1-expressing regulatory T cells in active generalized vitiligo and their clinical correlation.},
  author={Manoj Kumar Tembhre and Anita Singh Parihar and Vinod Kumar Sharma and Ajay K. Sharma and Parthaprasad Chattopadhyay and Shilpi Gira Gupta},
  journal={The British journal of dermatology},
  year={2015},
  volume={172 4},
  pages={
          940-50
        }
}
BACKGROUND Vitiligo is an autoimmune depigmentation disease, and defects in regulatory T cells (Tregs) have been proposed in the pathogenesis of generalized vitiligo (GV). However, the role of programmed cell death (PD)1(+) Tregs has not been studied. OBJECTIVES To investigate the status of Tregs, PD1(+) Tregs and associated parameters in active GV (aGV) during the first episode of disease attack and to establish the clinical correlation. METHODS The percentages of circulating Tregs, PD1… CONTINUE READING
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