Alteration in mitochondrial function and glutamate metabolism affected by 2-chloroethanol in primary cultured astrocytes.

@article{Sun2016AlterationIM,
  title={Alteration in mitochondrial function and glutamate metabolism affected by 2-chloroethanol in primary cultured astrocytes.},
  author={Qi Sun and Yingjun Liao and Tong Wang and Gaoyang Wang and Fenghong Zhao and Yaping Jin},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2016},
  volume={37},
  pages={50-60}
}
The aim of this study was to explore the mechanisms that contribute to 1,2-dichloroethane (1,2-DCE) induced brain edema by focusing on alteration of mitochondrial function and glutamate metabolism in primary cultured astrocytes induced by 2-chloroethanol (2-CE), a metabolite of 1,2-DCE in vivo. The cells were exposed to different levels of 2-CE in the media… CONTINUE READING