Alteration in methylation pattern of GATA-4 promoter region in vitamin A-deficient offspring's heart.

Abstract

Epigenetics might explain correlations between lifestyle and risk of disease. Maternal diet has been shown to dynamically alter epigenetic regulation, including affecting DNA methylation status. This study was designed to test the hypothesis that GATA-4 gene methylation would lead to congenital heart defects in vitamin A-deficient offspring. Ten weaning… (More)
DOI: 10.1016/j.jnutbio.2012.11.005

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