Alteration in insulin-like growth factor-binding proteins (IGFBPs) and IGFBP-3 protease activity in serum and urine from acute and chronic renal failure.

@article{Lee1994AlterationII,
  title={Alteration in insulin-like growth factor-binding proteins (IGFBPs) and IGFBP-3 protease activity in serum and urine from acute and chronic renal failure.},
  author={Dae Yeol Lee and Sang Kyun Park and Peter D. Yorgin and Pinchas Cohen and Y. L. Oh and Ron G. Rosenfeld},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1994},
  volume={79 5},
  pages={1376-82}
}
The insulin-like growth factors, IGF-I and IGF-II, are proteins that promote cellular growth and differentiation of various organs, including the kidney. These peptides interact with high affinity cell surface receptors and bind to a family of IGF-binding proteins (IGFBPs). Altered serum and urinary IGFBP patterns in children with chronic renal failure have been previously described. In this study, we evaluated serum and urinary IGFBP profiles in acute renal failure patients (ARF; n = 10) and… CONTINUE READING
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