Alteration in erythropoietin-induced cardioprotective signaling by postinfarct ventricular remodeling.

@article{Miki2006AlterationIE,
  title={Alteration in erythropoietin-induced cardioprotective signaling by postinfarct ventricular remodeling.},
  author={Takayuki Miki and Tetsuji Miura and Toshiyuki Yano and Akari Takahashi and Jun Sakamoto and Masaya Tanno and Hironori Kobayashi and Yoshihiro Ikeda and Masahiro Nishihara and Kazuyuki Naitoh and Katsuhiko Ohori and Kazuaki Shimamoto},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2006},
  volume={317 1},
  pages={68-75}
}
Postinfarct remodeling impairs mechanisms of ischemic preconditioning. We examined whether myocardial response to activation of the erythropoietin (EPO) receptor is modified by postinfarct remodeling. Four weeks after induction of myocardial infarction (MI) by coronary ligation in post-MI group (post-MI) or a sham operation in sham group (sham), rat hearts were isolated and subjected to 25-min global ischemia/2-h reperfusion. Infarct size was expressed as a percentage of risk area (i.e., left… CONTINUE READING