Alteration in cytoadherence and rosetting of Plasmodium falciparum-infected thalassemic red blood cells.

@article{Udomsangpetch1993AlterationIC,
  title={Alteration in cytoadherence and rosetting of Plasmodium falciparum-infected thalassemic red blood cells.},
  author={R Udomsangpetch and T Sueblinvong and Kovit Pattanapanyasat and A Dharmkrong-at and Aranya Kittikalayawong and H K Webster},
  journal={Blood},
  year={1993},
  volume={82 12},
  pages={3752-9}
}
  • R Udomsangpetch, T Sueblinvong, +3 authors H K Webster
  • Published 1993 in Blood
Hemoglobinopathies have a protective role in malaria that appears to be related to alterations in red blood cell (RBC) properties. Thalassemic RBCs infected with Plasmodium falciparum showed greatly reduced cytoadherence and rosetting properties as well as impaired growth and multiplication. A significant decrease in the levels of falciparum antigens associated with the membrane of infected beta-thalassemic RBCs was observed at trophozoite/schizont stage, but not young ring stage. This… CONTINUE READING
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